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Pica behavior is a validated endpoint to assess the ability of a compound to induce nausea/malaise in non-vomiting species, as mouse, based on the monitoring of non-nutritive (kaolin) food intake, as an index of gastrointestinal discomfort 43,44
It works by blocking certain signals in the brain that trigger nausea
Theoretical concerns in the hepatic-impairment context include: CYP3A4-metabolized drugs whose clearance may shift as liver function changes (not a direct ipamorelin interaction, but co-prescribed agents may behave differently as Child-Pugh stage evolves)
Readers asked about the side effects of GLP-1s, hitting weight-loss goals on different drugs and when major insurance companies will cover weight-loss drugs
If creatine helps during weight loss on a GLP-1, it helps for the same reason it helps during weight loss from any cause: it lets you train slightly harder, and the training is what moves body composition
Extended 16-week cycles are occasionally used for individuals over 250 pounds or those with extensive fat loss goals
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