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A study in mice showed that specific SCFAs accelerated -syn aggregation and microglial activation, whereas germ-free mice had delayed pathology [95]
This phenomenon, sometimes called therapeutic resistance, doesn't mean the medication is defectiveit means your body's peptide pathways may respond differently than others
However, significant, rapid weight loss can mess with your menstrual cycle, which may explain why some people experience missed, irregular, lighter, or shorter periods while taking tirzepatide
Normal weight fluctuation: Your weight can move up or down from day to day based on things like water, digestion, activity, and timing
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