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Acta 710 , 197211 (1982)

Immediately following injections, pramlintides plasma concentration spikes into pharmacological levels, which explains why nausea is the dose limiting adverse event, given that amylin receptors are in the vomit center of the brain

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Jendricke P et al

All data are expressed as the mean SD from at least three biological replicates, and comparisons between the two groups were performed with a nonparametric method (MannWhitney U test)