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IGF-1 LR3 is a modified IGF-1 with an extended amino acid sequence that has 13 additional amino acids at the N-terminus and a substitution of arginine for glutamic acid at position 3

Ideally 16 and above

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Indeed, diet-induced weight loss in knee or hip OA patients has previously been shown to slow disease progression, improve joint function, and reduce joint pain [79]

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In practical terms: once-daily SubQ injection of 12 mg is the most common protocol, prioritizing consistency over peak concentration