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5)
In clinical trials, tirzepatide produced average weight loss of up to 24.3% of body weight compared to approximately 15% with semaglutide
Importantly, the QMP-engineered GLP-1 albumin fusion did not only display improved PK properties, but also demonstrated a prolonged therapeutic effect in healthy human FcRn Tg32 mice challenged with a high dose of glucose
Lopez said the findings show that future studies should focus on comparing GLP-1s with clinically relevant comparators and use a target trial emulation to reduce biases
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