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Neurological injury: Cerebral and spinal cord IR during aortic surgery with circulatory arrest causes delayed paraplegia and cognitive dysfunction

3 PATHWAY GLUTATHIONE REDUCED FORM REDUCED GLUTATHIONE COFACTOR 1

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70 In C57BL/6J mice, CR promoted stress resistance in a FOXO1-dependent manner, 71 which would not occur in tumor cells with FOXO inactivation due to constitutively active AKT

In the enzymatic recycling system, glutathione reductase and NADPH regenerate free GSH from the mixed disulfide and any GSSG present, allowing repeated TNB formation and signal amplification

coli with the purpose of improving GSH production