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The discovery of GLP-1 receptor agonists' benefits for MCAS reminds us that healing often comes from unexpected places

GLP-1 receptor agonists should be considered when patients experience significant weight regain with BMI 27 kg/m with obesity-related comorbidities or BMI 30 kg/m, lifestyle modifications have been insufficient, no anatomical complications require surgical revision, and patients are willing to engage in long-term pharmacotherapy

10.1016/j.bbabio.2008.03.008

Chronic bioenergetic failure, characterized by impaired oxidative phosphorylation and a persistent ATP deficit, may underlie the profound fatigue and PEM in ME/CFS

Wang X, Chen T, Li C, et al

This system depends on tightly regulated anterograde and retrograde trafficking to deliver cargo and recycle components