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Although GLP-1RAs seem to have a beneficial influence in reversing many maladaptive brain changes relevant to depression, it should be remembered that at the same time, they are also known to mediate some unfavorable processes such as activation of the HPA axis and intensification of anxiety-like behavior in some animal studies
GLP-1 helps regulate appetite and gastric emptying
HbA1c, which reflects average glucose over 2-3 months, shows full treatment effect by month 3-4
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