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Interestingly, a few cases of differential metabolic changes (ie, fold change of MTX treatment over basal levels) were associated with MTX resistance (at 96 hours)

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Some novel GLP-1 RAs, such as PT302 and PT320, have data to show that they may reduce levodopa-induced dyskinesia and dopaminergic degeneration, suggesting a potential for synergistic therapy with levodopa