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When you do not have enough GSH to fight against free radicals, the resulting oxidative stress may lead to diseases like diabetes, rheumatoid arthritis, and Alzheimers disease

Patients with severe psoriasis and those with onset of psoriasis between the ages of 20 and 40 are thought to have elevated plasma levels of VEGF, VEGF alleles and VEGF receptors [42]

Elevated blood concentrations and gene expressions of pro-inflammatory cytokines including interleukin (IL)-1, IL-6, IL-8, interferon- (IFN-) and tumor necrosis factor- (TNF-) were demonstrated to be associated with depression [56, 57]

The interactions with the oxidative stress are resumed in figure 2

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