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Previous studies using genetic or small-molecule inhibitors of necroptosis via RIPK1/RIPK3/MLKL axis have given accumulating evidence regarding the essential role of necroptosis in ameliorating multi-organ inflammation such as skin inflammation (Lin et al., 2013), and inflammation of the pancreas (Wu et al., 2013), liver (Welz et al., 2011

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V., & Balachandran, B