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Also, inhibition of integrin signaling by the small molecule inhibitor SB273005 (integrin i) at a concentration that diminished focal adhesions by staining for paxillin, did not reduce actin patches and did not promote chromatin bridge breakage in cytokinesis compared with control cells (Fig

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The mechanism involves altered calcium channel activity, particularly affecting voltage-gated calcium channels (CaVs) and store-operated calcium entry pathways, leading to either excessive calcium influx or impaired calcium release from intracellular stores, ultimately resulting in cellular dysfunction and reduced fertilization potential (39)

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