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Mice treated with 150 mg/kg (about 900 mg for an adult human) or 300 mg/kg (about 1,800 mg for an adult human) of the extract had total cholesterol reductions of 14.2% and 7.1%, respectively, compared with the control group
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however, dedicated cardiovascular outcome trial (CVOT) data have not yet been published, and cardiovascular benefit has not been demonstrated Phase 3 trials are ongoing
reducing fat intake to under 30% of calories during the first month markedly improves tolerance in clinical trial participants
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"MOTS-c levels in human blood decline with age and correlate with insulin sensitivity, positioning the peptide not just as a metabolic tool but as a potential biomarker of mitochondrial vitality." On the exercise side, a pivotal finding came from studies measuring endogenous MOTS-c in human subjects
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