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Finally, although the total brain lipid content may decrease with age, the enzymes responsible for incorporating PUFAs into membrane phospholipids remain active, ensuring the continued presence of the necessary substrates for the final execution step of ferroptosis (75)

Cell Tissue Res., 377 (2):153-159

Those showing minimal early response may need dose adjustments, medication switching, or acknowledgment that their particular physiology responds less robustly to these receptor agonist approaches

PMID 24368434

While each system detoxifies specific peroxides via GPx or Prx, they share substrates and can compensate for one another when impaired

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