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My Clinical Take As a Performance Cardiologist GLP-1s will help millions
By using mice lacking hepatic TH receptor (TR) and a liver-specific TR-selective agonist, we demonstrate that TR-mediated hepatic TH signalling is required for both the regulation of GLP-1 production and the insulinotropic and glucose-lowering effects of T3
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These defects were accompanied by disrupted phosphorylation of the IRS, as well as down-regulated expression of mitochondrial proteins PPAR co-activator 1 (PGC1) and uncoupling protein-2 (UCP-2) [200]
The MRE located in the region near the MT promoter is targeted by MTF-1, whose expression is also inducible
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