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69 Conversely, the extracellular release of decorin (DCN, an extracellular matrix-derived damage-associated signaling proteoglycan), 70 high mobility group box 1 (HMGB1, an architectural DNA-binding factor in the cell nucleus), 71 and nuclear receptor coactivator 4 (NCOA4, a mediator of ferritinophagy) 72,73 may function as damage-associated alarm signals that promote inflammatory responses in the local microenvironment
Immunology 12, 686384
122 , 123 It is of interest that data from the USA Kernicterus Registry from 1992 to 2004 indicate that over 30% of kernicterus cases are associated with G6PD deficiency
(PubMed) Yang SJ, Hwang SY, Choi HY, et al
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Higher doses generally produce greater weight reduction, though some patients achieve excellent results on moderate doses
