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In vitro and animal studies have found that lipoic acid exhibits immunomodulatory properties through mechanisms that stimulate the production of cyclic AMP (cAMP) (90, 91) a central regulator of innate immune functions and inhibits the migration of immune cells into the brain and spinal cord (92), possibly by decreasing endothelial expression of cell adhesion molecules, inhibiting expression of enzymes like matrix metalloproteinases (MMP), and/or reducing the permeability of the blood-brain barrier (87, 89, 93, 94)

They tested these inhibitors in cell and animal models. They reported changes in intracellular nicotinamide-related metabolites and examined the biological effects of NNMT inhibition under experimental conditions. These outcomes have increased scientific interest in NNMT biology

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Key Features Research Use Only (RUO) compound 5 mg per bottle Spray format for convenient handling in laboratory settings Manufactured and packaged for research applications Product Specifications Compound Name: DSIP Form: Spray Total Quantity: 5 mg per bottle Grade: Research Use Only (RUO) Intended Use This product is intended solely for laboratory research and investigational purposes

Biochemical analysis Serum urea and creatinine levels were measured according to the methods of Rosenthal and Slot (Reference Rosenthal23,Reference Slot24)