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The report was uncontrolled, unblinded, not randomized, had no comparator arm, used patient-reported outcomes rather than validated pain instruments, and did not publish dose, effect size, confidence intervals, p-values, or systematically collected adverse events limitations that severely constrain any clinical inference

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Dependency on Maintenance Doses: Continuous maintenance may be required to preserve the whitening effect, adding to long-term costs

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In a phase 2 study, 18 patients with moderate to severe AH (MELD:11-28) were treated with two doses of F-652