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Melanotan I Read the full profile What it targets (One pigment switch (focused)) Peptide size/shape (Longer, straight-chain) Molecular weight (1,646.85 Da) Typical starting dose (0.250.5 mg/day) Typical upkeep dose (23x weekly) How long it lasts in the body (~0.5 hours) Given as a shot under the skin FDA-approved (as afamelanotide/Scenesse) Gentler, more limited side effects Melanotan II Read the full profile What it targets (Several switches (broad)) Peptide size/shape (Shorter, ring-shaped) Molecular weight (1,024.18 Da) Also affects appetite/libido Typical starting dose (0.250.5 mg/day) Typical upkeep dose (12x weekly) How long it lasts in the body (~1.5 hours) Given as a shot under the skin Our top-rated vendor Our rankings are based solely on third-party lab testing rigor, COA transparency, and pricing no paid placements, no affiliate influence