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Tirzepatide achieved superior reductions in HbA1c and body weight compared with once-weekly semaglutide in head-to-head testing. (Del Prato, The Lancet )

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A supplementary analysis focusing specifically on retinopathy found consistent results, with semaglutide showing higher reporting odds than other drugs

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The double bond and nitro group of this intermediate is reduced using either catalytic hydrogenation or by treatment with lithium aluminium hydride (method 5)