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It establishes an elevated risk of psychiatric consequences associated with these treatments, particularly in the domains of depression, anxiety, and suicidal outcomes

10.1016/j.cmet.2021.05.004 10 CaniP

What survives that test is narrower and more testable than the broad claim it replaces: that brain-penetrant agonism, delivered early, in patients chosen by their biology rather than their diagnosis, and judged against biomarkers rather than questionnaires, might still work

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