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Lillys R&D pipeline now includes: Next-gen tirzepatide analogs : Lilly has analogues of tirzepatide (to extend patent life) and related peptides in clinical trials
This structural advantage allows researchers to examine sustained, long-term GLP-1 signaling dynamics rather than the short-lived responses typical of endogenous hormones
Frontiers in Nutrition, 11, 1398059
There is also possible evidence suggesting a higher risk of depression, anxiety, and, potentially, suicidal thoughts (though some reports show antidepressant potential)
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