Clinical trials of semaglutide (STEP program) showed participants lost an average of 1518% of their body weight over 68 weeks, compared to 23% with placebo
Kawaida, K., Matsumoto, K., Shimazu, H
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The histological analysis of the biopsies of those patients revealed structural alteration in the dermis, as weight loss possibly affects the density of collagen and elastic fibers [7, 10,11,12]