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In paired secretagogue models, concurrent GHRH and GHRP activation has been shown to produce synergistic growth hormone release, reflecting two functionally distinct pathways that converge at the level of pituitary output

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Mechanistically, mutations in GNAS1 lead to constitutive activation of GNAS1 and the coupled protein adenylyl cyclase, resulting in an increase in intracellular cyclic adenosine monophosphate (cAMP) levels [38, 39]