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L-cysteine along with L-glutamic acid and glycine is the rate-limiting precursor in the synthesis of GSH peroxidase and has been found that high concentrations of L-cysteine reduced the tyrosinase activity and produced more pheomelanin by way of cysteinyl dihydroxyphenylalanine (DOPA), the building block of pheomelanin [Figure - 1]
Hydroquinone: A powerful skin-brightening agent, hydroquinone is often compounded with tretinoin to target hyperpigmentation and melasma
In the 26-week toxicity study in rats, females given approximately 16 and 25 times the clinical dose were more likely to be in diestrus
Jamali M, Majid A.J Pak Med Assoc
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