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Primary pain in ALS includes neuropathic pain and pain due to spasticity or cramps, whereas secondary pain is mainly nociceptive and may appear as muscle weakness and atrophy progress [83]
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In this review, we summarise the dynamic balance between reactive oxygen species (ROS) production and clearance, as well as the characteristics of various forms of cell death induced by ROS, including pyroptosis, apoptosis, necroptosis, autophagy, ferroptosis, cuproptosis, disulfidoptosis, oxeiptosis, and epigenetic regulation of these types of cell death
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In addition, when the UF animal model was being treated with LD the BCL-2 expression in the uterine tissue was significantly decreased with an increase in Bax mRNA expression, thus showing the apoptotic potential of LD in the treatment of UF (Li et al., 2013)
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