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doi: 10.1530/eje.0.1420231 79 Van DamAMMalinowskyDLenczowskiMJBartfaiTTildersFJ
Second-generation GLP-1 analogues, such as semaglutide, relative to first-generation analogues like exenatide or liraglutide, have previously shown enhanced efficacy compared to other GLP-1 analogues [24,25,26]
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Notably, disruption of aversion-related pathways does not eliminate the anorexigenic actions of GLP-1R agonists, highlighting NTS-derived GLP-1 signaling as a key contributor to their therapeutic efficacy [142]