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Studies show that glucocorticoids, commonly used to treat inflammatory conditions, cause significant decreases in bone formation that can lead to osteoporosis and increased fracture risk
Taken together, metformin may upregulate PKA signalling to exert its synergistic protective effects with liraglutide in both GLP-1R-dependent and -independent manners in PA-impaired endothelial cells
PMID: 41241376 Adnan SB et al
J.VagenaE.GalanakisD
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