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Dementia and depression have been associated with this deficiency as well, possibly from the under-production of methionine because of the inability to convert homocysteine into this product

Some patients need Vitamin B12 injections every two or three months for the rest of their life

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Since GHK-Cu levels naturally decline with age, ongoing periodic treatment helps maintain optimal tissue health and regenerative capacity

Some newer formulations (such as Egrifta SV) may remain stable at room temperature (2025C / 6877F) before mixing

Three-times-weekly dosing (often Monday, Wednesday, Friday) further reduces usage and extends supply to approximately 16 weeks at 2mg per dose