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Does that mean they don't work

The role of selenium is mainly played through selenoproteins synthesized by the selenium metabolic system

They also help researchers better understand the diseases mechanisms

Filli L, Schwab ME

PMCID: PMC9887785 Li W, Wang Z, Cao J, Dong Y, Chen Y (2023) Melatonin improves skin barrier damage caused by sleep restriction through gut microbiota

Any diagnostic or therapeutic inference drawn from the group-level GSH reduction therefore remains hypothesis-generating, and would need to be confirmed in larger, independent cohorts using longitudinal designs and ideally more objective indices of disease activity, such as prospective headache diaries or attack-phase measurements