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Ziaei et al

It occurs due to silencing or severe reduction of transcription of the FXN gene, encoding a mitochondrial protein which belongs to the FRATAXIN family, caused by the expansion of GAA trinucleotide repeats within its first intron

Antioxidants (Basel) 2021;10:1624

Trials comparing MI plus folate with folate alone have reported improvements in oocyte and embryo parameters.46 Wholesome Story uses L-methylfolate (MTHF), the biologically active form of folate, which does not require conversion in the body and is often chosen in reproductive-health formulations.47 Vitamin D3 (25mcg / 1,000IU) Vitamin D insufficiency is common in PCOS and has been linked to insulin resistance and metabolic dysfunction.48 Supplementation has been studied for modest improvements in insulin sensitivity and related markers, particularly in individuals who begin with low vitamin D status.49 50 The 1,000IU dose included here is above the recommended dietary allowance but remains well below established upper intake levels for adults, making it appropriate for ongoing daily use with a low risk of oversupplementation.51 One additional consideration is dosing flexibility

doi: 10.1111/head.13715 99

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