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van Rumund A, Green AJE, Fairfoul G, Esselink RAJ, Bloem BR, Verbeek MM

It is tempting to speculate that this apparent loss of benefit in patients with more advanced HF may be the result of increases in HR caused by activation of sinoatrial node (SAN) GLP-1Rs (64, 65), which could be mitigated with an agent such as GLP-1(2836) that retains cardiac and vascular protection of GLP-1, without activating the GLP-1R

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But a much stranger side effect is now forcing the food industry to rethink what ends up on our plates