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Sleep and Circadian Rhythm Studies DSIP has been employed in rodent models and neuronal cell lines to investigate sleep-promoting activity, phase-shifting properties, and oscillatory peptide expression

Bariatric Surgery as a Gold Standard : Bariatric surgery remains the most effective intervention for achieving substantial and sustained weight loss, particularly in patients with severe obesity

In the pituitary, GHRH binds to its receptor on somatotrophs and induces a rapid, dose-dependent release of GH, but also the transcription of the GH gene as well as the differentiation, growth, and proliferation of these cells

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