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Altered downstream signaling by the IR with the L973F substitution is certainly in large part mediated by the decrease in IRS-1 binding/phosphorylation and increase in Shc binding/phosphorylation, as shown in this study
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Ethics declarations Conflict of interest The authors declare that there exists no competing financial interest or personal relationships that could have appeared to influence the work reported in this paper
Low-dose betaine supplementation leads to immediate and long-term lowering of plasma homocysteine in healthy men and women
