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PTMs profoundly alter protein conformation, stability, enzymatic function, intracellular localization, and proteinprotein interactions by forming covalent bonds with specific amino acid residues on proteins
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All model parameters were assumed log-normally distributed
Endpoints The primary endpoint was the change from baseline in the mean amplitude of glycaemic excursions (MAGE) at week 24, which was assessed by CGMS
These risks are not being adequately communicated to patients, and shockingly, they are not listed in the official warning labels for most GLP-1 drugs
doi: 10.1186/s12933-017-0626-3 128 YueWLiYOuDYangQ
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