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Notably, post-mortem studies revealed reduced activity of respiratory chain complexes in a group of ASD children, suggesting that abnormalities, especially in the frontal, temporal and cerebellar areas (Tang et al., 2013), may cause mitochondrial impairment and contribute to the appearance of the first symptoms (Siddiqui et al., 2016)

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Its effects tend to be most noticeable in people with underlying metabolic or signaling disruptions such as insulin resistance or PCOS and more subtle in those with normal metabolic and reproductive function

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Certain beneficial gut microbes, such as Lactobacillus and Bifidobacterium , have been shown to stimulate the vagus nerve, leading to anxiolytic and antidepressant-like effects through the modulation of neurotransmitter release and HPA axis regulation [124, 150]

Simultaneously, it upregulates matrix metalloproteinases (MMPs) and their inhibitors (TIMPs), enabling coordinated tissue remodeling rather than simple collagen deposition