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Deficiency is widespread in the UK due to limited sunlight exposure, and is particularly prevalent in those with chronic illness, darker skin tones, or conditions affecting fat absorption

Hence this is also relevant to SOD1-mediated redoxosomal signaling defects in ALS (Kanekura et al., 2005

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They do not, however, recommend taking over-the-counter (OTC) supplements to prevent heart disease in those without risk factors

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