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Given its high affinity for eNOS (K m 23 M) and an intracellular concentration above 100 M, L-arginine is considered abundant in endothelial cells (Hardy and May, 2002)
Because this unique structure allows it to modulate a staggering number of biological processes
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doi:10.1016/j.biocel.2009.08.020 De Grandis D (2007) Acetyl-l-carnitine for the treatment of chemotherapy-induced peripheral neuropathy
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