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Obviously, the labeling of these meds is still pretty cautious on this, which is understandable, but Id argue that even with this reassuring evidence that we talked about that GLP-1 arent associated with suicide, we should honestly warn any patient about mood changes, depression, or suicidal ideation with any drug and refer them to help ASAP, such as contacting the crisis line at nine hundred eighty eight we mentioned earlier to keep them safe and of course, stop the med if there ever concerns for any of these symptoms
For people who aren't candidates for medication, can't afford it or prefer to start with lifestyle changes, focusing on GLP-1-supporting foods and habits can meaningfully improve appetite control and metabolic health
J Exp Med 215:2955
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However, when semaglutide is part of the picture, these ratios need some adjustment
