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reported a MOF nanosystem based on coordination between TCPP and Mn 3+ for selective tumor damage by redox-unlocked effect (Figure 2D) (Wan et al., 2019)

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Badr, K

Collectively, these recent contributions argue that future GSH-centric redox sensing and nanomedical approaches should (i) incorporate organelle targeting (especially mitochondria) to exploit subcellular redox heterogeneity, (ii) embed analyte-responsive activation into both therapeutic and imaging components, (iii) combine biochemical sensing with optical or thermal engineering for spatiotemporal control, and (iv) favor clinically translatable carriers (e.g., PLGA) for delivery

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Erjavec V, Vovk T, Nemec SA