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For DSIP with no identified receptor and no established axis the concept has no mechanistic anchor

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Towards prevention of diabetic peripheral neuropathy: clinical presentation, pathogenesis, and new treatments

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May Support Appetite Regulation Semaglutide works with GLP-1 receptors that may help regulate appetite signaling - supporting reduced cravings and a greater sense of fullness between meals

[18] showed that intravenous infusion of GLP-1 for 48 hours in animal models with induced dilated cardiomyopathy significantly improved LV contractility, stroke volume, and cardiac output