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The use of CoA in metabolic signaling relates to the roles of various acylated CoA molecules, such as acetyl-CoA, crotonyl-CoA, that serve to acylate lysine residues in the nuclear histone proteins, such as is the case for nuclear acetyl-CoA, succinyl-CoA, butyryl-CoA, and propionyl-CoA

Salivary biomarkers of oxidative stress: a critical review

doi:10.1017/s0029665116000744 Concha-Meyer A, Palomo I, Plaza A, et al

It means there is no established data on how these peptides behave in human pharmacokinetics, what adverse events occur at what frequencies, or what drug interactions are possible

But biological plausibility does not replace human clinical trial proof