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While there's no single "best" time for drug administration, you can experiment to find what works for you

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Animal studies documented significant brain concentrations after oral administration, with cognitive effects comparable to subcutaneous injection

Indeed, after injury Notch ligands (Khazaei et al., 2020) and myelin-associated factors such as Nogo (Wang et al., 2015) are upregulated in the spinal cord microenvironment and bias differentiation of transplanted cells toward more astrocytes

"Again, that's just a rumor

Dropping excess weight can also make it easier to work out, and, as Elle Woods famously pointed out in Legally Blonde , Exercise gives you endorphins