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Other studies have successfully used ethyl chloroacetoacetate as a starting material to produce ethyl (R)-4-chloro-3-hydroxybutyrate with high optical purity via asymmetric catalytic hydrogenation, which is then converted into L-carnitine

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These drugs are effective for some people, but they can have side effects

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A meta-analysis of 37 randomized controlled trials established this with reasonable confidence

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