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Despite lack of statistically significant outcome, 42.0% of patients treated with obexelimab (21/50) showed improvement compared to 28.6% on placebo (12/42) (P = 0.183)

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The treatment given to this patient resulted in an improved microbiome with an increase in bacterial diversity, partly due to an increase in the relative abundance of butyrate-producing bacterial species, which were paralleled by an increase in butyrate concentration, an anti-inflammatory SCFA (Engen et al., 2020)

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