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These active forms are crucial cofactors for enzymes involved in DNA synthesis, fatty acid metabolism, and amino acid metabolism

[Article] [PubMed]10

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IV glutathione has real limitations

Institute of Medicine Panel on Micronutrients (2001)

For example, gene silencing or pharmacological inhibition of ROS-scavenging, upregulation of ROS-generating enzymes, or pro-oxidant therapy can induce excessive oxidative stress, leading to cell death (12)