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Failure to eliminate dysfunctional mitochondria leads to the accumulation of mitochondrial ROS and the release of immunogenic mtDNA, both of which act as DAMPs that activate innate immune pathways, including the NLRP3 inflammasome and type I interferon (IFN-I) signaling

3,4 This is why GLP-1 RAs were initially studied exclusively for diabetes management

Cortisol and Stress-Related Eating Caffeine can also elevate cortisol levels, often referred to as the stress hormone. While cortisol is necessary for alertness, chronically high levels can lead to increased appetite for high-calorie, sugary foodsthe very types of food that can impede weight loss progress

It has not received approval from Health Canada for therapeutic use, meaning it cannot be prescribed or marketed as a treatment

Semaglutide Is the Better-Evidenced Agent Several randomized trials conducted between 2021 and 2025 showed semaglutide 1.02.4mg weekly produces roughly 1015% weight loss in PCOS patients over 612 months, with parallel improvements in menstrual cycle frequency, testosterone, sex hormone-binding globulin (SHBG), and HOMA-IR (a marker of insulin resistance)

These physician-supervised protocols are tailored to your individual wellness needs for meaningful, lasting results