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In parallel, hyperglycemia-induced oxidative stress activates multiple pathological signaling cascades, including PKC, which further disrupt endothelial function and precipitate abnormal blood flow, vascular leakage, and neovascularization, hallmarks of DR (102104)

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Nanoparticles also serve as multifunctional delivery vehicles capable of co-transporting antioxidants, growth factors, and other regenerative agents

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