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12 These outcomes are consistent with a maintained postprandial metabolic effect but note the important confound: in these trials cagrilintide is almost always studied with semaglutide, so cleanly attributing the postprandial glucose benefit to cagrilintides gastric or glucagon effects specifically is not straightforward

Downstream saturation / spare receptor full physiological response often achieved well below full occupancy because the cells downstream signaling pathway has its own ceiling

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