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To avoid problems due to species specific differences in drug transporters at the BBB [36] human cell-based models are preferable

42 The ECL1 was not resolved in the first two structures, and the third map showed that the ECL1 closely interacted with PACAP38 (pituitary adenylate cyclase activating polypeptide-38) without detailed residue contact information due to limited resolution

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Using MAGeCKflute CutoffCalling, we compared the gene hits by categorysensitizers (those whereby a loss sensitizes to 5FU) and resisters (those whose loss promote insensitivity to 5FU)and we observed several metabolic genes in both (Fig